ZFHX3 and atrial fibrillation: Therefore, the minor allele of the rs2106261 ZFHX3 polymorphism might modulate the expression of paired-like homeodomain 2c, promoting the proliferation of the myocardial sleeve around the branches of the pulmonary vein, increasing automaticity, which then serves as an AF trigger.[34,35] Under this circumstance, AF is related to the pulmonary vein and thus could be cured by pulmonary vein isolation.