Previous GWAS have shown that the single-nucleotide polymorphism (SNP) rs2106261 in the zinc finger homeobox 3 (ZFHX3) gene at chromosome 16q22 is strongly associated with susceptibility to AF.[7] The association between allele T at rs2106261 and AF has been replicated in several populations. This evidence concerns the gene ZFHX3 and atrial fibrillation.