This risk variant was first discovered to be significantly associated with AF in 5 community-based cohorts in the United States and Iceland, with results replicated in a Germany cohort.[25] Soon afterward, a study by Li et al[10] showed that the minor allele of rs2106261 was related to AF susceptibility in a Chinese Han population, expanding the association between ZFHX3 and AF in individuals of non-European ancestry. The gene discussed is ZFHX3; the disease is atrial fibrillation.