Wu et al [17] used univariate and LASSO Cox regression analysis to develop a m6A regulator prognostic signature composed of HNRNPC, METTL3, HNRNA2B1, IGF2BP1, and IGF2BP2 for lung adenocarcinoma based on RNA-seq, clinicopathological, and single nucleotide variation data retrieved from the TCGA database.[17] Also, Yang et al[18] found that HNRNPC and KIAA1429 can be regarded as potential prognostic markers in papillary renal cell carcinoma by using the similar method. This evidence concerns the gene VIRMA and lung adenocarcinoma.