The negative correlation between RBP4 and the severity of liver fibrosis might be due to the decreased level of RBP4, which participated in the activation of hepatic stellate cell overexpression and the deposition of type I collagen in the liver, that promoted the progression of liver fibrosis [12, 23], which eventually developed into liver cirrhosis or HCC. The gene discussed is RBP4; the disease is hepatocellular carcinoma.