The data presented here agrees with our previous study examining hippocampal activity (Gan et al. 2011), with PAR2 activation reducing neuronal activity in both brain regions but how these ex vivo findings relate to depression-like behaviour remains to be elucidated as is the consequence of PAR2 activation on neuronal firing in other brain regions associated with depression-like behaviour. The gene discussed is F2RL1; the disease is major depressive disorder.