ABCC11 and obesity due to melanocortin 4 receptor deficiency: These loci included the canonical example of selection at the MCM6 gene, which regulates the neighboring LCT gene and contributes to the lactase persistence trait (Bersaglieri et al. 2004), the ABCC11 gene regulating earwax production, several pigmentation-related genes, as well as genes associated with obesity, diabetes and addiction (table 1).