Expression of 6 of 14 immune-cell metagene clusters and 13 of 29 potential immunotherapy targets such as PD1, PD-L1, and CTLA4 was also significantly decreased in metastatic breast cancer samples, suggesting an immune-cell-depleted and immunosuppressive microenvironment in metastasis via downregulation of chemotactic and immune-activating cytokines, and decreased antigen presentation. The gene discussed is CD274; the disease is breast cancer.