In this trial, PD-L1 expression was assessed by the PD-L1 IHC 22C3 pharmDx assay and was determined with CPS, defined as the number of PD-L1-positive tumor cells, lymphocytes, and macrophages divided by the total number of tumor cells multiplied by 100; specimens with a CPS ≥ 1 were considered PD-L1-positive[113]. The gene discussed is CD274; the disease is neoplasm.