ERBB2 and breast carcinoma: At the time of this writing, three antibody-drug conjugates have been approved by the United States Food and Drug administration (FDA) for breast cancer: ado-trastuzumab emtansine (T-DM1) for metastatic and early stage HER2-amplified or overexpressing breast cancer (2013, 2019)[73,74], fam-trastuzumab deruxtecan-nxki (DS-8201) for metastatic HER2-positive breast cancer (2019)[75] and sacituzumab govitecan (SG, IMMU-132) for metastatic TNBC following ≥ 2 prior lines of therapy in the metastatic setting (2020)[76].