IL17A and rheumatoid arthritis: For example, a study by Hu et al. revealed that miR-23a showed downregulated expression in articular cartilage tissues of patients with rheumatoid arthritis, and it could inhibit the interleukin-17- (IL-17-) mediated expression of proinflammatory mediators by targeting IKKα [8], and a study by Wade et al. pointed out that miR-23a decreased in synovial tissues of patients with psoriatic arthritis, and its decreased expression can induce activation of synovial fibroblasts [9].