According to difference analysis and correlation analysis, we finally identified the immune cells commonly associated with IGLL5 and IL2RA in ccRCC and pRCC, such as CD8+ T cells, Tregs cells and T follicular helper cells, which was consistent with prior studies (Roth et al., 2018; Cañete et al., 2019; Ohue et al., 2019). Here, CD8A is linked to nonpapillary renal cell carcinoma.