Interestingly, these three signatures were developed by different teams using different logical rationale and were mostly nonoverlapping with only one common gene, MLH1, which protein product heterodimerizes to form MutL alpha (Lindner et al., 2021; Pannafino and Alani, 2021), important actor of the DNA mismatch repair system that is widely associated with the Lynch syndrome known as hereditary nonpolyposis CRC, and MSI (Yamamoto and Imai, 2019; Lindner et al., 2021; Stinton et al., 2021). The gene discussed is MLH1; the disease is Lynch syndrome.