Similarly, in another large-scale analysis across 8,656 TCGA tumor samples, recurrent mutations generating alternative splice junctions were identified in various tumor suppressor genes (e.g., TP53, GATA3, PTEN, SETD2, DDX5, BCOR, SPOP, KDM6A, SMAD4, and BAP1) (Jayasinghe et al., 2018). This evidence concerns the gene KDM6A and neoplasm.