ESR1 and Sepsis: PAS scores for the AR, ER, MAPK-AP1, FOXO-PI3K, JAK-STAT1/2, JAK-STAT3, Notch, Hedgehog, TGFβ, and NFκB pathways were measured using target gene expression data of whole blood samples from clinical studies on children (Supplementary Figures 1–6) and adults with sepsis and septic shock (Supplementary Figures 7, 8).