The NFκB pathway (termed NFκB or TLR) (23, 24, 26, 27), the MAPK pathway (termed “p380MAPK, PDGF”) (24, 26–28), the JAK-STAT3 pathway (termed “IL6, IL10”) (24, 26–28), and the PI3K-FOXO pathway (termed “Integrin signaling/Insulin signaling/IGF1 signaling”) (26), were identified as associated with sepsis, but without information on activity state of these pathways. Here, STAT3 is linked to Sepsis.