Nfκb2 gene is rearranged in about 2% of human B- and T-cell leukemias/lymphomas, non-Hodgkin’s Lymphomas, B-cell chronic lymphocytic leukemia (CLL) and multiple myelomas (Neri et al., 1991; Fracchiolla et al., 1993; Migliazza et al., 1994; Thakur et al., 1994; Zhang et al., 1994). The gene discussed is NFKB2; the disease is B-cell chronic lymphocytic leukemia.