In the present research, we discovered that METTL3 catalyzes m6A modification of hsa_circ_0058493, and the methylation site of hsa_circ_0058493 could bind to YTHDC1 and export it from the nucleus to the cytoplasm in a m6A-dependent manner, ultimately promoting HCC progression (Figure 8). Here, METTL3 is linked to hepatocellular carcinoma.