Downregulation of these TFs results in the acquisition of progenitor cell characteristics and increased ADM and PanIN formation, highlighting the importance of maintained expression of these identity factors to prevent tumor initiation (Miyamoto et al., 2003; De La et al., 2008; Shi et al., 2009; Flandez et al., 2014; von Figura et al., 2014; Krah et al., 2015). The gene discussed is ADM; the disease is neoplasm.