PMCH and Down syndrome: Currently, the MCH-FS was primarily used to assess feeding difficulty in children with risk factors, such as premature (3), esophageal atresia (EA) (6, 22, 23), agenesis of the corpus callosum (ACC) (24), congenital heart disease (25), asthma (26), Down's syndrome (27), and autism spectrum disorder (ASD) (28), but less is known about the association between MCH-FS and health and development in the normal population.