In colon cancer, HOXB-AS3 can competitively bind to arginine residues in the RGG motif of hnRNP A1 by encoding a conserved 53-aa peptide, thus blocking hnRNP A1 dependent pyruvate kinase M(PKM) splicing, PKM2 formation and subsequent colon cancer cell metabolic reprogramming to inhibit tumorigenesis. This evidence concerns the gene PDS5B and malignant colon neoplasm.