Besides, lncRNA SATB2-AS1 directly binds to WDR5 and GADD45A, cis-activating SATB2 transcription via mediating histone H3 lysine 4 tri-methylation deposition and DNA demethylation of the promoter region of SATB2, thus inhibiting CRC transfer and modulating CRC immune response (34). This evidence concerns the gene GADD45A and colorectal carcinoma.