ACACB and cancer: Interestingly, though FA oxidation and FA synthesis (FAS) are used to be considered incompatible on account of the suppressive effect of malonyl-CoA (a fatty acid synthesis intermediate) on FAO, there have been studies countering this argument in leukemia and breast cancers (51, 52) and findings in acidic-adapted cancer cells proved that the concomitance of FAO and FAS were allowed by histone deacetylation-mediated acetyl-CoA carboxylase 2 (ACC2) inhibition (51–53).