CAR-T cells are mainly against TAAs that overexpress in CRC, including CEA, EGFR, mesothelin, MUC-1, NKG2D ligand, HER2, c-met, CD133, GUCY2C, epithelial cell adhesion molecule (EpCAM), and Tumor-associated glycoprotein (TAG)-72 (18, 157). This evidence concerns the gene CEACAM5 and colorectal carcinoma.