Almost all SHH-MB contain at least one driver event, most frequently affecting PTCH1, SUFU, TP53 or SMO, KMT2D/2C, HAT, GPR161 and ELP1; with germline mutations in TP53 and ELP1 mostly identified in older pediatric medulloblastoma patients (16, 18–20). This evidence concerns the gene SMO and medulloblastoma.