The less common non-nodal (leukemic) variant (nnMCL), on the other hand, is derived from post-germinal center/memory-like B cells that are generally characterized by mutated IGHV, lack of SOX11 expression, low genomic complexity, and an indolent clinical behavior that is partially related to the lack of angiogenic or tumor invasive properties (2–4). The gene discussed is SOX11; the disease is neoplasm.