These considerations inspired the cIMPACT recommendations for classification of diffused gliomas and the last revision of the World Health Organization (WHO) classification for central nervous system (CNS) tumors, which suggested considering isocitrate dehydrogenase (IDH)-mutant and IDH-wild-type cancers as two separate entities due to the importance of IDH mutation for patient survival (5, 6). Here, IDH1 is linked to cancer.