In this regard, dysregulation of the MAPK pathway in cancers can trigger mutations in BRAF, and KRAS and subsequently, KRAS can motivate Ras– Raf–ERK pathways.22 Recent studies revealed the crucial role of the Ras–Raf–ERK in the motivation of tumor cells migration and proliferation.23,24 In the current investigation, we established that miR‐193a‐5p and -146a-5p are pivotal factors for the inhibition of both ERK pathways and are essential for the suppression of CRC cell growth, proliferation, and migration. The gene discussed is KRAS; the disease is cancer.