Lu et aldesignated the reduced expression of miR-146a-5p in CRC and considered this miRNA as a tumor suppressor gene.17 In another study, Zhang et al designated that the expression of miR-193a-5p in colorectal tumor samples was significantly reduced in comparison with healthy samples, and this reduction correlated with the metastasis to the lymph nodes and mortality rate in suffered patients.18 Considering these facts, the current investigation was planned to examine the impacts of these miRNAs in colorectal tumor progression either alone or in combination with each other. The gene discussed is ENSG00000280371; the disease is neoplasm.