Given that these MSCs are influenced by inflammatory cytokine such as TNFα, the aim of this study is the assessment of infliximab effects on MSC immunomodulatory functions through evaluation the IDO, iNOS, and PGE2 expressions in a co-culture of MSCs with allogeneic peripheral blood mononuclear cells (PBMCs) isolated from patients diagnosed with GVHD. The gene discussed is TNF; the disease is graft versus host disease.