Nowadays, a lot of research is done to address the molecular mechanisms causing the low quality of oocytes.13,30 Identification of a subpopulation of GCs to exhibit a pluripotent and self-renewing potential opens new horizons in augmenting new therapeutic strategies for patients suffering from ovarian insufficiencies.22,26 We showed that the culture of GCs with LIF increased the expression of OCT3/4 while down-regulated GATA-4 in GCs. Here, GATA4 is linked to ovarian dysfunction.