Recent studies have reported that GSIs are useful in the eradication of BCSCs, inhibition of EMT, angiogenesis, and tumor growth.19,26,27 Besides, GSIs also potentiate the effect of chemotherapeutic agents by inhibiting the genes involved in chemoresistance (Hes and Hey).28,29 Existing evidence also suggests that the inhibition of DLL4 mediated activation of Notch receptors by anti-DLL4 mAb also produce anti-angiogenic, proapoptotic and chemo-sensitizing effects on TNBC cells.30-32 It was recently reported that a combination of DLL4 mAb with GSIs has synergetic proapoptotic effects.33 This evidence concerns the gene DLL4 and neoplasm.