Transcription factor (TF) ETS1 participates in a variety of pathological and biological processes, such as oncogenesis, cell differentiation, apoptosis, and proliferation [38–40], and the aberrant expression of ETS1 has been proven to correlate with the development, invasion, and migration in various types of malignance, including breast cancer [41], prostate cancer [42], colorectal cancer [43], hepatocellular carcinoma [44], gastric cancer [45], and NSCLC [46]. This evidence concerns the gene ETS1 and colorectal cancer.