It may increase the competitive inhibition of B-cell lymphoma 6 DNA binding elements by the signal transducer and activator of transcription 3 through phosphorylation of this protein, thereby weakening the inhibitory effect of B-cell lymphoma 6 on monocyte chemoattractant protein 1, promoting the production of inflammation, and contributing to the development of atherosclerosis [25]. The gene discussed is STAT3; the disease is atherosclerosis.