Thus, we investigated whether the gut microbiota regulates the mechanism of OSA-associated hypertension, sleep architecture, and mTOR signaling pathway by evaluating the gut microbiota, polysomnography (PSG) data, and mTOR levels of peripheral blood mononuclear cells (PBMCs) of severe-OSA patients with hypertension and those without hypertension. This evidence concerns the gene MTOR and obstructive sleep apnea syndrome.