And, the present research demonstrated that QFG downregulated the ratio of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR, while upregulated the ratio of p-AMPK/AMPK, which showed that QFG may induce autophagy in CRC via the mTOR signaling pathway and can inhibit the EMT by inducing autophagy and decreasing the level of TWIST1 and increasing the level of beclin-1. The gene discussed is AKT1; the disease is colorectal carcinoma.