VIM and neoplasm: In the progression of malignancy, the downregulation of E-cadherin expression, the transformation of E-cadherin to N-Cadherin on the cell membrane surface, and the conversion of cytokeratin cytoskeleton into vimentin-based cytoskeleton (increased expression of vimentin) indicate that the adhesion ability of tumor cells is decreased, and the ability of movement, invasion, and metastasis is enhanced.