Furthermore, the TRPM4 mRNA expression levels of the MG-NAFL, MG-NASH and MG-fibrosis mice were higher than those of the CG-NAFL, CG-NASH and CG-fibrosis mice, and this expression decreased after Gexia Zhuyu decoction intervention, indicating that the TRMP4 channel was activated under pathological conditions, such that TRPM4 mRNA was highly expressed in normal cells. The gene discussed is TRPM4; the disease is metabolic dysfunction-associated steatohepatitis.