Compared with MG-NASH mice, in GXZY-NASH mice, serum TC, TNF-α, and IL-6 levels and liver MDA and TC contents (3.89 ± 0.24 nmol/L, 67.93 ± 6.10 ng/L, 19.70 ± 2.85 ng/L, 3.73 ± 0.47 nmol/ml, and 1.51 ± 0.16 nmol/L, n = 10) decreased after decoction administration, and the SOD content (48.11 ± 2.71 nmol/ml) increased. This evidence concerns the gene IL6 and metabolic dysfunction-associated steatohepatitis.