In MG-NASH mice, serum TC, TNF-α, and IL-6 levels and liver MDA and TC levels (5.12 ± 0.25 nmol/L, 97.71 ± 7.00 ng/L, 30.66 ± 6.00 ng/L, 6.06 ± 1.37 nmol/mL, and 1.92 ± 0.14 nmol/L, n = 10) increased, while the SOD content (41.13 ± 3.11 nmol/mL) decreased. Here, SOD1 is linked to metabolic dysfunction-associated steatohepatitis.