Gexia Zhuyu decoction can increase the expression level of miRNA-24, target and regulate TRPM4 protein channel, improve the abnormal activation state of TRPM4 channel, silence TRPM4 mRNA expression, promote intracellular Na+ and Ca2+ concentration and membrane potential changes to return to normal, reduce cells' internal ROS levels, improve liver cell damage caused by NAFLD at various stages, and correct metabolic dysfunction. The gene discussed is TRPM4; the disease is metabolic dysfunction-associated steatotic liver disease.