It is hoped that through the construction of circTADA2As/miR-203a-3p/SOCS3 network targeted therapy for breast cancer is a good prognostic molecular marker for triple-negative breast cancer [14]; other studies have shown that circular RNA also plays an important role in breast cancer resistance; for example, hsa_circ_0025202 in HR-positive breast cancer has an anticancer effect, which can be achieved through the miR-182-5p/FOXO3a axis and can be used as a new marker for tamoxifen resistance [15]. This evidence concerns the gene FOXO3 and breast cancer.