But the most remarkable pro-cancer RAD52 phenotype is seen in cancer cells deficient in any of the following DNA repair proteins: BRCA1, BRCA2, PALB2, XAB2 or RAD51 paralogs: RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 (Feng et al., 2011; Chun et al., 2013; Lok et al., 2013; Sharma et al., 2021). The gene discussed is XRCC2; the disease is cancer.