IGHE and urticaria: In particular, the food allergy diagnosis was based on three converging lines of evidence: (1) history consistent with IgE-mediated immediate hypersensitivity reactions (i.e., urticaria, lip swelling, vomiting, diarrhea) following exposure to egg, peanut, hazelnut, sesame, sunflower seed, tuna, and liquid cow’s milk); (2) positive epicutaneous skin prick testing to cow’s milk, salmon, peanuts, treenuts, and seeds, as well as multiple environmental allergens, including tree and grass pollen, cat, dog, and dust mite; and (3) the presence of serum-specific IgE.