NFKB1 and neoplasm: Moreover, a genome immune coprecipitation experiment revealed that AQB significantly inhibited NF-κB in the CD274 gene promoter region, and that HOTAIR overexpression reversed and promoted NF-κB enrichment in this area, implying that AQB may regulate the immune sensitivity of tumor cells by inhibiting the transcriptional regulation of CD274 gene by NF-κB (Figure 5C).