Simultaneously, HOTAIR was highly positively correlated with the tumor immune escape related protein PD-L1; furthermore, it was negatively correlated with the expression of NFκB repressing factor (NKRF), Protein Kinase C Theta (PRKCQ) and ubiquitin-associated and ubiquitin regulatory X domain-containing protein 1 (UBXN1), which are repressors of the NF-κB signaling pathway. The gene discussed is CD274; the disease is neoplasm.