Proteinuria, immunoglobuin depositon in kidney, and glomerulonephritis as well as IgG1 and IgG2a in serum decreased. CD4 IFNγ+ Th1 cells and the ratio of Th1/Th2 decreased. CD69 and CD71 expression on CD4+ T cells as well as CD4+ T cell proliferation was inhibited, CD4+ T cell apoptosis increased. This evidence concerns the gene CD4 and glomerulonephritis.