SIRT1 and rheumatoid arthritis: There have been preclinical and clinical studies indicating the significance of SIRT1 in the pathogenesis of Ads, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), multiple sclerosis (MS), etc. In women Hashimoto’s disease patients with type 1 diabetes mellitus, SIRT1 contributed to the pathogenesis of early cardiac dysfunction (10).