Not surprisingly, our transcriptomic analysis revealed downregulation of genes encoding for TJ and AJ proteins in enteroids grown from chronic SIV-infected RhMs. Downregulation of claudin-3, 4, and 7 was also reported in other intestinal inflammatory diseases like ulcerative colitis and Crohn’s disease (74, 75). The gene discussed is CLDN3; the disease is ulcerative colitis.