NBR1 and pachyonychia congenita: identified NBR1-mediated selective macroautophagy/autophagy of MHC-I hindered cancer cell recognition and clearance by CD8+ T cells in PC (11), and granulin secretion by metastasis-associated macrophages activates resident hepatic stellate cells into myofibroblasts, resulting in a fibrotic microenvironment that sustains metastatic PC growth (12).