In addition, it was discovered the expression of S100A2 in tumor tissues was remarkably positively correlated with the expression of PD-L1 (Figure 8A, P = 0.001, r = 0.25) and CTLA-4 (Figure 8A, P <0.01, r = 0.23), especially PD-L1. Here, CD274 is linked to neoplasm.