IL36G and infection: Interestingly, whereas no major differences in innate cell infiltration to the lungs between IL-36γ-/- and WT mice were identified during the first 6 days of infection, a surprising difference was that IL-36γ-/- mice showed massive apoptosis of alveolar macrophages, leading to a rapid reduction of alveolar macrophages in the lungs of these mice (70).