Because MAB-hR3 disrupts the recruitment of IL-1RAcP, other inflammatory signals mediated by IL-1α, IL-1β and IL-33 were also disrupted in vitro and in vivo models of local and systemic inflammation models in mice such as peritonitis, OVA-induced airway allergy and Imiquimod-induced psoriasis (114). The gene discussed is IL1B; the disease is psoriasis.