RNF20 and Hepatic fibrosis: Besides, ring finger protein 20 (RNF20), also known as E3 ubiquitin-protein ligase BRE1A, has been demonstrated to inactivate IL-6, TNF-α, VEGFA, α-SMA as well as collagen I and alleviate liver fibrosis via ubiquitination of H2BK120 (H2BK120ub) in vitro and in vivo (Table 1; Figure 2) (Chen et al., 2021).