Besides, transgenerational high-fat diet (HFD) feeding reduced H3K9me2 accumulation at promoters of LXRα and endoplasmic reticulum oxidoreductin-alpha (ERO1-α) in the offspring mice, which account for the up-regulation of lipogenesis and endoplasmic reticulum (ER) stress in the development of obesity and hepatic steatosis (Li et al., 2012). Here, NR1H3 is linked to Hepatic steatosis.