Lgr5+ intestinal stem cells (ISCs) are the progenitors of secretory cells and enterocytes that produce mature intestinal epithelial cells, so ISCs are also the cancer stem cells for CRC, as shown by lineage tracing studies (Barker et al., 2009; Merlos-Suarez et al., 2011; Kemper et al., 2012). Here, LGR5 is linked to colorectal carcinoma.