In CRC, multiple studies have shown that the de novo synthesis of fatty acids is enhanced with the upregulation of critical enzymes, including ATP citrate lyase (ACLY), acetyl CoA carboxylase (ACC), and fatty acid synthase (FASN) (Zaytseva et al., 2012; Hofmanova et al., 2021). Here, ACLY is linked to colorectal carcinoma.