In addition, Heintza’s work illustrates that the repression or inhibition of CYP2B (e.g., CYP2B10) may exacerbate metabolic disorders and cause obesity by perturbing fatty acid metabolism, suggesting a role of CYP2B in lipid homeostasis (Heintz et al., 2019). The gene discussed is CYP2B6; the disease is obesity due to melanocortin 4 receptor deficiency.