Table 2 shows the genotype distribution and allele frequency of the Pro12Ala PPARγ2 polymorphism in males and females classified according to weight category. A significant difference in the prevalence of Ala12Ala genotype was observed between females with and without obesity (6.3 and 0.2%, respectively; Fisher’s test: p = 0.003). No differences were observed in males. The analysis of the association of the genotypes with the anthropometric variables in males and females (Table 3) showed similar results. This evidence concerns the gene PPARG and Obesity.