In this sense, the relationship of the PPARγ2 polymorphisms with obesity, insulin sensitivity and lipid profile has been extensively investigated, mainly in adults, with inconsistent results (Deeb et al., 1998; Mori et al., 1998; Mancini et al., 1999; Ringel et al., 1999; Altshuler et al., 2000; Hara et al., 2000; Oh et al., 2000; Douglas et al., 2001; Ek et al., 2001; Masud et al., 2003; Rosmond et al., 2003; Radha et al., 2006; Tönjes et al., 2006; Florez et al., 2007). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.