IL17A and systemic lupus erythematosus: In addition, it has been proven that improved T helper cell 17 (Th17) amount and effect play a crucial role by secreting pro-inflammatory cytokines, such as interleukin (IL)-17 and IL-23), as the primary trigger of autoimmune response, and these cytokines are related to the inflammatory formation and tissue damage in SLE (Crispín et al., 2008; Doreau et al., 2009; Chen et al., 2010; Pan et al., 2013).