As the anti-dsDNA titer increased, the frequency of the Synergistetes, which was positively associated with the rate of Firmicutes to Bacteroidetes in healthy controls, verged to decrease in SLE patients and was present a significantly negative association with the level of proinflammatory cytokines IL-6 in serum, meanwhile, correlating positively with natural protective IgM anti-phosphorylcholine secreted by B1 cells (López et al., 2016). This evidence concerns the gene IL6 and systemic lupus erythematosus.