IGF1 and hypertensive disorder: IGF-1 deficiency also impairs the production and release of vasomediator eicosanoids from astrocytes, alters endothelial nitric oxide production, and increases susceptibility to hypertension-induced microhemorrhages (Toth et al., 2015; Tarantini et al., 2017, 2021a; Fulop et al., 2019).