PTGS2 and congenital primary aphakia: In addition to astrocytes, microglia play roles in COX-2-mediated neuroinflammation (Font-Nieves et al., 2012) and astrocyte-microglial interactions (Bernaus et al., 2020; Matejuk and Ransohoff, 2020), they may be activated during CPA procedure and contribute to CPA formation.