Similarly, individuals with bipolar disorder also have clinical and preclinical evidence for immune dysregulation, with the elevation of proinflammatory cytokines relative to psychiatric and normal controls, including IL-6, tumor necrosis factor (TNF)-α, IL-1β, soluble receptor of TNF-type 1 (STNFR1), and soluble interleukin-2 receptor (sIL-2R) [78–84]. The gene discussed is TNF; the disease is bipolar disorder.