FASN and colorectal carcinoma: To assess whether FASN could be detected in exomeres, we first showed that it is highly enriched in exomeres from DiFi cells by FAVS (Extended Data Fig. 7j) and then, as proof-of-principle, we detected higher levels of FASN in exomeres isolated from the plasma of a patient with CRC compared with a control (Fig. 7l).