In G1 (CRP normal: n = 277, 5-year OS 93%—median OS not yet reached, CRP 5–20 mg/l: n = 38, 5-year OS 85%—median OS not yet reached, CRP > 20 mg/l: n = 12, 5-year OS 87%—median OS not yet reached; p = 0.357; Fig. 2a ) and G3 (CRP normal: n = 26, 5-year OS 25%—median OS 25 months, CRP 5-20 mg/l: n = 14, 5-year OS 43%—median OS 22 months, CRP > 20 mg/l: n = 13, 5-year OS 8%—median OS 14 months; p = 0.210; Fig. 2c) differentiated tumours, a similar trend could be observed, which was not statistically significant likely due to insufficient statistical power. Here, CRP is linked to neoplasm.