INS and diabetic cardiomyopathy: Cardiac tissue in diabetic mice revealed upregulation in diabetic cardiomyopathy and cardiac contractility pathways including calcium signaling pathway (path:mmu04020, P.DE = 2.83e−3), oxidative phosphorylation (path:mmu00190, P.DE = 7.85e−3), cardiac muscle contraction (path:mmu04260, P.DE = 7.85e−3), diabetic cardiomyopathy (path:mmu05415, P.DE = 1.68e−2), and insulin secretion (path:mmu04911, P.DE = 2.89e−3) (Table 2).