ATR and cancer: In agreement with the logogriphic sensitivity results, we observed that the following key regulators: ATM/ATR, Mad2:Cdc20P, APC/CP:Cdc20, Cdc25, and Cdc20P are significantly more sensitive to parameter perturbations in p53-null cancer cells as compared to p53-wt cancer cells when both cell types are tested in the Plk1-depletion condition (see Supplementary Fig. 6).