For example, expression of DUX4, an activator of the zygotic genome in humans, in muscle cells leads to Facioscapulohumeral muscular dystrophy (FSHD), and OCT4 and Nanog are overexpressed in undifferentiated tumors and their expression is associated with poor clinical outcomes10,66–71. This evidence concerns the gene DUX4 and facioscapulohumeral muscular dystrophy.